Quantification of Myocardial Flow Reserve Using Positron Emission Imaging: The Journey to Clinical Use

Of the many advantages of positron emission tomography (PET) imaging, its ability to quantify biological parameters is often identified as the most important. Yet, data linking PET-derived parameters to outcomes are often lacking. In this issue of the Journal, Herzog et al. (2) present one of the first studies to evaluate the prognostic value of PET-derived quantification of coronary flow reserve (CFR) using 13N-ammonia (13NH3) in patients with suspected ischemia and the first to evaluate its added prognostic value compared with relative myocardial perfusion imaging (MPI). Such evaluation is a key step on the journey to establish the clinical role of this approach.

Beanlands et al, J. Am. Coll. Cardiol. 2009;54:157-159
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