Clinical Advantages

Clinical Advantages of Ammonia N-13

Today a majority of Cardiologists cite better diagnostic/prognostic capabilities as one of the most important reasons for adding cardiac PET to their practice. While making the decision to move to cardiac PET imaging is important, the choice of radiopharmaceutical can be just as important if not more so. 

Up until now, the choice was limited to a Rb-82 generator for the vast majority of imaging facilities. This was because they are not in close proximity to a cyclotron to receive radiopharmaceuticals with short half lives. Additionally, they do not have the budget for such a large capital investment required for ownership of a full size cyclotron. Today, there is no longer a need to compromise with cardiac PET. Ionetix can provide any facility, anywhere in the world with Ammonia N-13 on-demand. 

Below are the key clinical and workflow advantages for using Ammonia N-13 to take your cardiac PET program to the next level.

Image Quality

A shorter positron range typically results in image quality improvement when switching from Rb-82 Chloride to Ammonia N-13.

Ionetix Ammonia N-13 for PET Imaging comparison of Image Quality Rb-82 vs Ammonia

Optimal Radiopharmaceutical for Myocardial Blood Flow

With Ammonia N-13, there is less roll off at higher flows, better extraction, resulting in fewer correction factors.

Two polar maps showing the difference in correction factors using Ionetix Ammonia N-13 for Myocardial Blood Flow PET Imaging

Potential for Treadmill Stress

  • Expands PET patient selection1
  • Reliable diagnostic accuracy in obese patients2
  • Larger defects compared to Dipyridamole3
Doctor performing an Ionetix Ammonia N-13 treadmill stress test on a patient
  1. Aggarwal NR, Drozdova A, Askew JW, Kemp BJ, Chareonthaitawee P. Feasibility and diagnostic accuracy of exercise treadmill nitrogen-N-13 Ammonia PET myocardial perfusion imaging of obese patients. Journal of Nuclear Cardiology. 2015 Dec 1;22(6):1273-80.
  2. Chow BJ, Al Shammeri OM, Beanlands RS, Chen L, DaSilva J, Ruddy TD. Prognostic value of treadmill exercise and dobutamine stress positron emission tomography. Canadian Journal of Cardiology. 2009 Jul 1;25(7):e220-4.
  3. Chow BJ, Beanlands RS, Lee A, DaSilva JN, Alkahtani A, Ruddy TD. Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography. Journal of the American College of Cardiology. 2006 Jan 17;47(2):411-6.