Potential for Treadmill Stress

An Alternative to Pharmacologic Stress

The longer half-life of Ammonia N-13 can allow for patients to be treadmill exercised as an alternative to pharmacologic stress. This provides additional imaging options for your cardiac PET program and expands patient selection.

Recent studies utilizing treadmill Ammonia N-13 stress testing have demonstrated:

  • Reliable diagnostic accuracy and image quality in obese and non-obese patients. 1
  • Annual event rate is consistent with previously published SPECT and PET data. 2
  • Produces larger, more severe defects compared to dipyridamole stress. 3
Doctor performing an Ionetix Ammonia N-13 treadmill stress test on a patient
  1. Aggarwal NR, Drozdova A, Askew JW, Kemp BJ, Chareonthaitawee P. Feasibility and diagnostic accuracy of exercise treadmill nitrogen-N-13 Ammonia PET myocardial perfusion imaging of obese patients. Journal of Nuclear Cardiology. 2015 Dec 1;22(6):1273-80.
  2. Chow BJ, Al Shammeri OM, Beanlands RS, Chen L, DaSilva J, Ruddy TD. Prognostic value of treadmill exercise and dobutamine stress positron emission tomography. Canadian Journal of Cardiology. 2009 Jul 1;25(7):e220-4.
  3. Chow BJ, Beanlands RS, Lee A, DaSilva JN, Alkahtani A, Ruddy TD. Treadmill exercise produces larger perfusion defects than dipyridamole stress N-13 ammonia positron emission tomography. Journal of the American College of Cardiology. 2006 Jan 17;47(2):411-6.