Radiopharmaceutical Comparison

Radiopharmaceutical Comparison

Ammonia N-13, due to the low mean positron length associated before the proton annihilates, has been shown to provide clearer images potentially allowing for an improved diagnostic certainty. The following PET scan images is an example Ammonia N-13 compared to Rb-82 Chloride.

Physical properties2Ammonia N-13Rb-82 Chloride
Half life (min)9.971.27
Positron decay100%95.5%
Positron range (mm)0.572.60
Image Resolution (mm) FWHM58
Effective radiation (mSv/MBq)0.0020.0034
Raw materialHigh Purity O-16 water and methane gasSr-82/Sr-85
SuppliedUnit DoseGenerator
Physiological properties1Ammonia N-13Rb-82 Chloride
PhysiologyDiffusible/retainedExtracted/retained
 RestStressRestStress
Extraction fraction 0.98 0.93 0.700.40
Retention fraction 0.87-0.970.56-0.650.47-0.550.27-0.28
Ionetix Ammonia N-13 Radiopharmaceutical for PET Imaging perfusion images in black and white SA and HLA view
Ionetix Ammonia N-13 for PET Imaging perfusion images compared to Rb-82 Chloride Radiopharmaceutical
  1. deKemp et. al. “Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow?” J. Nucl Cardiol 2007; 14:380-97
  2. Sabin, MG, Radiopharmaceuticals for Nuclear Cardiology: Radiation Dosimetry, Uncertainties, and Risk, J Nucl Med 2008; 49:1555-1563