Coronary Flow Reserve

CFR Overview

The seminal concept of coronary flow reserve (CFR) was proposed experimentally by Dr. Lance K. Gould in 1974. Coronary reserve is the capacity of the coronary circulation to dilate following an increase in myocardial metabolic demand and can be expressed by the difference between the hyperemic flow and the resting flow curve. In 1979, this data was validated by Dr. Gould using PET imaging techniques utilizing radiolabeled microspheres. 2 Ammonia N-13 coronary flow reserve measurements are very well established in the medical literature.

Consider adding a cardiac PET program to your current service line. cardiac PET can be a quality solution for ensuring lower healthcare costs while improving patient outcomes. 

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These advantages correlate with improvements in procedure accuracy and sensitivity compared to SPECT, particularly for heavier patients, where breast, chest wall, and diaphragmatic attenuation interfere with conventional SPECT.

  1. Gould KL, Lipscomb K, Hamilton GW. Physiologic basis for assessing critical coronary stenosis: instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. The American journal of cardiology. 1974 Jan 31;33(1):87-94.