Methods of measuring coronary blood flow by quantitative PET imaging requires measuring the arterial input function as well as assessing the retention of the radiopharmaceutical uptake.
The arterial input function is obtained by region of interest during the first 120 seconds of acquisition. Several locations of the region of interest are practical. However, some are better than others.
Most software packages are automated for the determination of the arterial input function (AIF).
- selection typically at basal plane of LV and LA
- some software allows for manual choice
- best AIF could differ between stress and rest